Details
In this webinar, Dr. Nixon covers the following topics:
- The lysosomal network
- Lysosomes and cellular aging
- Why are neurons so vulnerable?
- Genetics of late onset neurodegeneration
- Alzheimer’s disease – a lysosomal disease
- Consequences of lysosomal dysfunction
Dr. Nixon is Professor of Psychiatry and Cell Biology at New York University Langone Medical Center and the Director of the Center for Dementia Research at the Nathan S. Kline Institute. Dr. Nixon’s research was the first to establish the importance of proteases and defective proteolytic systems in the pathogenesis of Alzheimer’s disease and has identified new therapeutic approaches for the disease. A major focus of Dr. Nixon’s research is on the pathogenic importance of endosomal-lysosomal dysfunction in neurodegenerative diseases, which revealed presenilins as essential for lysosome function and presenilin mutations, the most common cause of early onset Alzheimer’s Disease, as key accelerants of the disease through lysosomal mechanisms.
