List of Nutriceuticals

NutraceuticalProposed Effect on Brain cellsReferenceRecommended Seller shared with BBDF, if any                   
Proposed effect notes in red are cautionary as are their associated references
4 Sight antioxidant (alpha lipoic acid, ginkgo biloba, Lutein, Zeaxanthin, Lycopene, Zinc)Anti-oxidant; Anti-inflammatory; NeuroprotectionSee each ingredient listedOrthomolecular
7,8-DHF7,8-DHF is neuroprotective in many animal models, and there is a biological rationale for increasing BDNF signaling through TrkB. However, no human studies have been conducted.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/7-8-Dihydroxyflavone-Cognitive-Vitality-For-Researchers.pdf
AcetylcarnitineAnti-inflammatory; Anti-oxidant; NeuroprotectionGiovanna Traina. The neurobiology of acetyl-L-carnitine. Frontiers in Bioscience. Landmark, 21, 1314-1329. June 1, 2016.Biotics
Aged Garlic ExtractAnti-oxidantBungorn Sripanidkulchai. Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action. Review Exp Ther Med. 2020. Feb;19(2):1560-1564.
Alpha GPCNeuroprotectionhttps://www.alzdiscovery.org/uploads/cognitive_vitality_media/Alpha-GPC-Cognitive-Vitality-For-Researchers.pdf
Alpha Lipoic AcidInhibits aldose reductase, which prevents leakage of anti-oxidants from eye tissue; recharges ALA vitamin C, E and glutathione; acts as an Anti-oxidant, Anti-inflammatoryVenigalla M, Sonego S, Gyengesi E, et al. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. Review. Neurochem Int. 2016. May;95:63-74.
Andean shilaijtAnti-inflammatory; Anti-oxidantCarrasco-Gallardo, Guzman L and RB Maccioni. Shilajit: A Natural Phytocomplex with Potential Procognitive Activity. Int J Alz Dis. Vol 2012.
ApigeninPreclinical evidence suggests strong Anti-inflammatory and Anti-oxidant but no clinical trials have been performed. May interfere with drug metabolism.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Apigenin-Cognitive-Vitality-For-Researchers.pdf
ArjunaAnti-oxidant; Anti-atherogenic agent of the heart (not investigated for Neurodegeneration)Dwivedi S and D Chopra. Revisiting Terminalia arjuna - An Ancient Cardiovascular Drug. J Tradit Complement Med. 2014. Oct-Dec:224-331.
AzaphilonesInhibits fromation of protein aggregates (in Alzheimer's Disease)SR Paranjape. Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. ACS Chem Neurosci. 2015. May 20;6(5):751-760.
B-AsaroneSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol. 2020; 8:555408.
Bacopa MonieriAnti-inflammatory; Anti-oxidanthttps://www.alzdiscovery.org/uploads/cognitive_vitality_media/Bacopa-Monnieri-Cognitive-Vitality-For-Researchers.pdf
BaicaleinSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Biotin (Vitamin B7)Key role in glucose metabolism and homeostasisDO Kennedy. B Vitamins and the Brain: Mechanisms, Dose and Efficacy - A Review. Nutrients. 2016. Feb;8(2):68.
Black Currant OilAnti-oxidant; Neuroprotection; Inhibits formation of neurotoxic aggregatesSubash S, Essa MM, Al-Adawi S. Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res. 2014. Aug 15; 9(16):1557-66.
CaffeineSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Calcium (as Calcium Citrate)Homeostasis of Calcium in the brain is important for normal cell-cell communication. High concentrations of calcium may contribute to the progression of neurodegenerative disease.Marambaud P, Dreses-Werringloer U and V Vingtdeux. Calcium signaling in neurodegeneration. Mod Neurodegener. 2009;4:20.
CarbohydratesLeads to neuroinflammation which may accelerate disease.Perlmutter, D., & Loberg, K. (2013). Grain brain: the surprising truth about wheat, carbs, and sugar--your brain's silent killers.
Chia OilAnti-inflammatory; Anti-oxidantMartinez Leo, EE and MR Segura Campos. Neuroprotective effect of Salvia hispanica peptide fractions on pro-inflammatory modulation of HMC3 microglial cells. J Food Biochem. 2020. Vol 44, Iss 6.
Chromium (as Chromium Polynicotinate)Homeostasis of chromium metal important for brain health. High concentrations of metals may contribute to progression in neurodegenerative diseases.Jomova K, Vondrakova D, Lawson M, et al. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem. 2010. 345:91–104.
Citrus BioflavonoidsAnti-inflammatory; Anti-oxidant; NeuroprotectionHwang S-L, Shih P-H, Yen G-C. Neuroprotective effects of citrus flavonoids. J Agric Food Chem. 2012. Feb 1;60(4):877-85.
Coenzyme Q10 (Ubiquinone)Anti-oxidant; NeuroprotectionPark HW, Park CG, et al. Intrastriatal administration of coenzyme q10 enhances neuroprotection in a Parkinson's disease rat model. Sci Rep. 2020;10:9572.
ConophyllineSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Copper (as Copper Bisglycinate Chelate)Component of anti-oxidant enzyme, Superoxide Dismutase. Because copper and zinc compete with each other for absorption, individuals taking high amounts of zinc can develop a copper deficiency. NB- excess copper contributes to neurodegeneration“Copper Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, Health and Human Services, 3 June 2020, ods.od.nih.gov/factsheets/Copper-HealthProfessional/Albion Minerals
Ejaz HW, Wang W, and M Lang. Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics. Review Int J Mol Sci. 2020. Oct 16;21(20).
Cucurbitacin ESupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol. 2020. 8:555408.
Curcumin (Thorne Meriva 500-SF)Anti-oxidant; Supports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.Thorne
Pohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.Thorne
DendrobineSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol. 2020. 8:555408.
Delphinidins (Metabolite of Pomegranate juice)Anti-oxidantMazumder MK, Choudhury S and A Borah. An in silico investigation on the inhibitory potential of the constituents of Pomegranate Juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases. IBRO Rep. 2019. Jun;6:153-159.
Epigallocatechin-3-gallateAnti-oxidant; Neuroprotectionhttps://www.alzdiscovery.org/uploads/cognitive_vitality_media/EGCG-Cognitive-Vitality-For-Researchers.pdf
Uddin M, Mamun A, Kabir T, et al. Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration. E J Pharm. Nov 5, 2020. Vol 886, 1723412.
Pohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
Ferulic AcidAntioxidantPohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
Fish Oil "DHA"Anti-oxidant; Anti-InflammatoryYamagata K. Dietary docosahexaenoic acid inhibits neurodegeneration and prevents stroke. J Neurosci Res. 2020. Sep 23.
Folate (Vitamin B9 given as Quatrefolic-L-5-Methyltetrahydrofolate, glucosamine salt)Neuronal integrity; Neural PlasticityCraenen K, Verslegers M, Baatout S, et al. An apprraisal of folates as key factors in cognition and ageing-related diseases. Review Crit Rev Food Sci Nutr. 2020;60(5):722-739.
Kronenberg G, Colla M, Endres. Folic acid, neurodegenerative and neuropsychiatric disease. Curr Mol Med. 2009. Apr;9(3):315-323.
GeraniolSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Gingko bilobaNeuroprotective Potential in Retinal diseasePohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
Neuroprotective Potential of Ginkgo biloba in Retinal Diseases. Planta Med. 2019. Nov;85(17):1292-1303.
GlutathioneAnti-oxidantA Moustapha Neurodegenerative Diseases: Potential Effect of Glutathione, Glutathione System and Oxidative Stress in Health and Disease, Margarete Dulce Bagatini, Intech
GlutenLeads to neuroinflammation which may accelerate disease.Perlmutter, D., & Loberg, K. (2013). Grain brain: the surprising truth about wheat, carbs, and sugar--your brain's silent killers.
Mohan M, Okeoma CM, Sestak K. Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies. Int J Mol Sci. 2020. Jul 29;21(15):5407.
Green TeaObservational studies suggest GT maybe neuroprotective. GT is safe BUT should not be harvested from areas where there is excessive pollution which could lead to lead contamination and adverse effects on the brain.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Green-Tea-Cognitive-Vitality-For-Researchers.pdf
Huperzine AAnti-oxidant. Huperzine A improved some aspects of memory and cognition in patients with vascular dementia and
Alzheimer’s disease in clinical trials; however, many caveats prevent drawing firm conclusions. Appears
safe for short-term use but evidence for long-term safety is lacking.
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Huperzine-A-Cognitive-Vitality-For-Researchers.pdf
Pohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
L-CarnitineNeuroprotection from oxidative stress.Calvani M, Carta A, Caruso G, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann NY Acad Sci. 1992. Nov 21;663:483-486.
In 1996, researchers at the University of Missouri published their findings of decreased plasma levels of carnitine in children with CLN3 disease. In 2020, researchers at the NICHD could not confirm the same results and noted that children with CLN3 disease do not show symptoms of carnitine deficiency such as muscle weakness and liver problems. Mancuso C, Bates TE, Butterfield DA, et al. Natural antioxidants in Alzheimer’s disease. Expert Opin. Investig. Drugs. 2007;16:1921–1931
Katz M. Decreased plasma carnitine and trimethyl-l-lysine levels association with lysosomal accumulation of trimethyl-l-lysine containing protein in Batten disease. BBA 1996 16 Dec;192-98.
An Dang Do, MD; NICHD, personal communication, September 15, 2020
L-TheaninePositive short-term effects on cognitive function, blood pressure, and sleep, but no studies have tested its effects on dementia or neurodegeneration. https://www.alzdiscovery.org/uploads/cognitive_vitality_media/L-Theanine-Cognitive-Vitality-For-Researchers.pdf
Limonoids (AKA D-Limonene)Supports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Lipoic acid (Biotics)Anti-oxidantKastaniotis AJ, Autio KJ, Nair RR, et al. Mitochondrial Fatty Acids in Neurodegenerative Disorders. Neuroscientist. 2020 Jul 9;1073858420936162
LuteinNeuroprotection from oxidative stressPark HA, Hayden MM, Bannerman S, et al. Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules. 2020. Jul 29;25(15):3453.
LuteolinNeuroprotection, Anti-inflammatory Kempuraj D, Thangavel R, Kempuraj DD, et al. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. Biofactors. 2020.
LycopeneNeuroprotection from oxidative stressPark HA, Hayden MM, Bannerman S, et al. Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules. 2020. Jul 29;25(15):3453.
Magnesium (as TRAACS Magnesium Bisglycinate Chelate Buffered)Nerve transmission, protective against excessive excitation which can lead to neuronal cell death. Excessive excitation (glutamate toxicity) has been reported in CLN3 disease. Evidence suggests that higher intake or circulating levels of magnesium (Mg) is associated with a reduced risk of dementia and a number of age-related diseases. Whether supplemental Mg above recommended levels is beneficial is unknown.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Magnesium-Cognitive-Vitality-For-Researchers.pdf
The Role of Magnesium in Neurological Disorders. Nutrients. 2018. Jun;10(6):730.
Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the CLN3(delta ex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. Neurochem Int. 2011.
Manganese (as Manganese Glycinate)Manganese is a cofactor for many enzymes, including manganese superoxide dismutase, which is important for inhibiting oxidative stress leading to neuronal cell death“Manganese Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, Health and Human Services, 3 June 2020, https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/
Excessive levels lead to neurotoxicityYan D-Y and B Xu. The Role of Autophagy in Manganese-Induced Neurotoxicity. Front Neurosci. 2020. Sep 15;14:574750.
Meganatural-AZAnti-oxidantPasinetti GM, Ksiezak-Reding H, Santa-Maria I, et al. Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. J Neurochem. 2010. Sep;114(6):1557-68.
MelatoninFights neurodegeneration via cellular clearance. Known to be safe for healthy adults to regulate circadian rhythm and improve sleep. Not recommended for dementia patients.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Melatonin-Cognitive-Vitality-For-Researchers.pdf
Stacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol. 2020; 8:555408.
Micro-antioxidentMixture of Anti-oxidants - Arjuna, Vitamin B12, Niacinamide, Pyrioxine AKG, Citrus Bioflavonoids, Super Oxide Dismutase, Glutathione, Pyruvate, Sulforaphane, Ornithine, Chia Oil, BiotinSee each ingredient listedEpic
MitoQConsistent evidence suggests that MitoQ can reduce oxidative stress in cellular batteries (mitochondria); though whether
this will impact health outcomes in humans is unknown.
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/MitoQ-Cognitive-Vitality-For-Researchers.pdf
MorinAnti-inflammatoryBen-Azu B, Aderibigbe AO, Ajayi AM, et al. Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia. Int Immunopharmacol. 2019. May;70:338-353.
MolybdenumLiver detoxification [only studied in neurodegeneration caused by Molybdenum deficiency, listed here as part of the MultiVitamin and Mineral Base (see below)]. “Molybdenum" Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, Health and Human Services, 3 June 2020, https://ods.od.nih.gov/factsheets/Molybdenum-HealthProfessional
Multi Vitamin and Mineral BaseMixture - Vitamin A, Vitamin C, Vitamin D-3, Vitamin E, Vitamin K, Thiamine, Riboflavin, Niacin, Vitamin B-6, Folate, Biotin, Vitamin B-12, Pantothenic Acid, Calcium, Iodine, Magnesium, Zinc, Selenium, Copper, Manganese, Chromium, MolybdenumSee each ingredient listed
N-Acetylcystein (NAC)NAC supplementation is protective in patients
undergoing heart surgery and those with COPD, but no studies have tested whether it improves outcomes in pediatric or adult forms of neurodegeneration. Preclinical studies are weak. Amylyx reports NAC/TUDCA more promising but still too weak. see SPB/TUDCA in State of Therapeutic Science section of BBDF website
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/N-acetylcysteine-Cognitive-Vitality-For-Researchers.pdf
NAC/TUDCANAC (precursor of cysteine which increases the level of glutathione in the brain); TUDCA (a hydrophilic bile acid with cell preservation and anti-oxidant properties)Garg G, Sandeep S, Singh AK, et al. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Can J Physiol Phamacol. 2018. Dec;96(12):1189-1196.
Alhasani RH, Almarhoun M, Zhou X, et al. Tauroursodeoxycholic Acid Protects Retinal Pigment Epithelial Cells from Oxidative Injury and Endoplasmic Reticulum Stress In Vitro. Biomedicines. 2020. Sep 21;(9):367.
NAC/TUDCA results have led to advanced studies with SPB/TUDCA by Amylyx in Alzheimer's disease and amyolateral sclerosis (ALS). See Pagaoni S, Macklin EA, Hendrix S, et al. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyolateral Lateral Sclerosis. N Engl J Med. 2020 Sep 3;383(10):919-930. Gun Show Supplements
Neurosyn - blend of sulbutiamine form of B1, huperzine A (HUPA), Alpha GPC, Acetyl L-Carnitine, PhosphatidylserineMixture - Sulbutiamine form of B1, huperzine A, Alpha GPC, Acetyl L-Carnitine, Phosphatidylserine.See each ingredient listedSystemic
Neuroprotectin D1anti-inflammatory; neuroprotectionAsatryan A and NG Bazan Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. JBC. 2017. Jul 28:292 (30):12390-97.
Niacin (Vitamin B3 given as Niacinamide)NeuroprotectionFricker RA, Green EL, Jenkins SI, et al. The Influence of Nicotinamide on Health and Disease in the Central Nervous System. Int J Tryptophan Res. 2018. May 21;11:1178646918776658.
OleocanthalAnti-oxidantGiusti L, Angeloni C, Barbalace MC, et al. A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress. Int J Mol Sci. 2018. Aug 8;19(8):2329.
Pantothenic Acid (Vitamin B5 given as as Calcium Pantothenate)Vitamin B5 deficiency occurs in some adult forms of neurodegeneration. No studies done in CLN3 disease.Xu J, Patassini S, Begley P, et al. Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease. Biochem Biophys Res Commun. 2020. Jun 30;527(3):676-681.
Phosphatidylserine13-14% fatty acid composition of a healthy brain. May promote cognitive function and be neuroprotectivehttps://www.alzdiscovery.org/uploads/cognitive_vitality_media/Phosphatidylserine-Cognitive-Vitality-For-Researchers.pdf
Kim, H-Y, Huang BX, Spector AA. Phosphatidyserine in the Brain: Metabolism and Function. Prog Lipid Res. 2014. Oct;0:1-18.
Pomegranet ExtractSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Mazumder MK, Choudhury S and A Borah. An in silico investigation on the inhibitory potential of the constituents of Pomegranate Juice on antioxidant defense mechanism: Relevance to neurodegenerative diseases. IBRO Rep. 2019. Jun;6:153-159.
PorphrazymeAccording to Biotics Research, Porphyra-Zyme™ supplies botanical extracts and concentrates, providing naturally occurring chlorophyllin, galactoglycerides, chlorophyll, and other phytonutrients to support the normal, healthy elimination of toxic metals. Metal accumulation has been documented in several forms of neurodegeneration. Sharma S, Wakode S, Sharma S, et al. Effect of environmental toxicants on neuronal functions. Environ Sci Pollut Res Int. 2020. Sep 29.Biotics
Pro-OmegaEicosapentaenoic Acid; Docosahexaenoic Acid; Other Omega-3sSee each ingredient listedNordic Naturals
PyruvateAnti-inflammatoryGarabadu D, Agrawal N, Sharma A, et al. Mitochondrial metabolism: a common link between neuroinflammation and neurodegeneration. Behav Pharmacol. 2019. Dec;30(8):642-652.
QuerceptinSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Pohl F and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
ResveratrolFights neurodegeneration via autophagy in vitro with minimal effects in trial which may due to poor availability in brain tissue.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Resveratrol-Cognitive-Vitality-For-Researchers.pdf
Stacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
Pohl F, and PKT Lin. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo, and clinical trials. Molecules. 2018. Dec 23(12):3283.
Riboflavin (Vitamin B2 given as Riboflavin 5 Phosphate)Anti-oxidant; Anti-InflammatoryAjibawo-Aganbi U, Saleem S, Ali Khan SZ, et al. Can Nutritional Adequacy Help Evade Neurodegeneration in Older Age? A Review. Cureus. 2020. Oct 12;12(10).
Suwannasom N, Kao I, Georgieva R, et al. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int J Mol Sci. 2020. Jan 31;21(3):950.
SageSome evidence suggests that the herb Sage can provide acute cognitive benefits, though there are
concerns over the standardization of treatment.
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Sage-Cognitive-Vitality-For-Researchers.pdf
Selenium (as L-Selenomethionine)Anti-inflammatoryLandgraf AD, Alsegiani AS, Alaqel S, et al. Neuroprotective and Anti-inflammatory Properties of Ebselen Derivatives and Their Potential to Inhibit Neurodegeneration. ACS Chem Neurosci. 2020. Oct 7:11(9):3008-3016.
ShankhpushpiAnti-Oxidant; Anti-Inflammatoryhttps://www.alzdiscovery.org/uploads/cognitive_vitality_media/Shankhpushpi-Cognitive-Vitality-for-researchers.pdf
SugarLeads to neuroinflammation which may accelerate disease.Lustig RH. (2012) Pure, White and Deadly: How Sugar is Killing us and What We Can Do to Stop It. Revised from first publication in 1972.
Perlmutter, D., & Loberg, K. (2013). Grain brain: the surprising truth about wheat, carbs, and sugar--your brain's silent killers.
SulforaphaneAnti-oxidantLi D, Shao R, Wang Na, et al. Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress. Autophagy. 2020. Mar 15;1-16.
Super Oxide DismutaseAnti-oxidantLiu Z, Zhou T, Ziegler AC, et al. Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxid Med Cell Longev. 2017;17:2525967.Supports clearance of cellular waste
TrehaloseSupports clearance of cellular wasteStacchiotti A and G Corsetti. Natural Compounds and Autophagy: Allies Against Neurodegeneration. Front Cell Dev Biol, 2020; 8:555408.
VinpocetineA few clinical trials suggest several potential benefits of vinpocetine including memory improvement and increased cerebral blood flow and metabolism. It is likely safe for short term use, but the safety of chronic use has not been tested.https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Vinpocetine-Cognitive-Vitality-For-Researchers.pdf
Vitamin A (as Ascorbic Acid)Supports neural patterning, differentiation, and axon outgrowthDas BC, Dasgupta S, Ray SK. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural Regen Res. 2019. Nov; 14(11):1880-1892.
Vitamin A (As Vitamin A Palmitate)Supports neural patterning, differentiation, and axon outgrowthDas BC, Dasgupta S, Ray SK. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural Regen Res. 2019. Nov; 14(11):1880-1892.
Vitamin B12 (as Methylcobalamin)Supports health, trending but not proven to treat neurodegenerative diseaseAjibawo-Aganbi U, Saleem S, Ali Khan SZ, et al. Can Nutritional Adequacy Help Evade Neurodegeneration in Older Age? A Review. Cureus. 2020. Oct 12;12(10).
Vitamin CAnti-oxidantKocot J, Luchowska-Kocot D, Kielczykowska M, et al. Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? Nutrients. 2017. Jul;9(7):659.
Vitamin D3 (as Cholecalciferol)UnknownKoduah P, Paul F, and J-M Dorr. Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases. EPMA J. 2017. Dec;8(4):313-325.
Vitamin E (as MixedTocopherols)Supports health, trending but not proven to treat neurodegenerative diseaseAjibawo-Aganbi U, Saleem S, Ali Khan SZ, et al. Can Nutritional Adequacy Help Evade Neurodegeneration in Older Age? A Review. Cureus. 2020. Oct 12;12(10).
Vitamin K1Neuroprotection; Anti-InflammatoryAlisi L, Cao R, De Angelis C, et al. The Relationships Between Vitamin K and Cognition: A Review of Current Evidence. Front Neurol. 19 March 2019.
ZeaxanthinAnti-OxidantLakey-Beitia J, Kumar J, Hegde M, et al. Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis. Int J Mol Sci. 2019. Nov;;20(22):5553.
Zinc (as Zinc Picolinate)Zinc homeostasis critically important for numerous brain functionsPortbury SD and PA Adlard. Zinc Signal in Brain Diseases. Int J Mol Sci. 2017. Dec; 18(12): 2506.
Zinc (s TRAACS Zinc Bisglycinate Chelate)Zinc homeostasis critically important for numerous brain functionsPortbury SD and PA Adlard. Zinc Signal in Brain Diseases. Int J Mol Sci. 2017. Dec; 18(12): 2506.