• The Natural History of Neuropsychological, Behavioral, and Psychiatric Symptoms in Late Infantile and Juvenile Neuronal Ceroid Lipofuscinosis
• Autoimmune Response in Batten Disease
• Autoimmunity to Glutamic Acid Decarboxylase(GAD) in the neurodegenerative disorder Batten disease
• National Institute of Neurological Disorders and Stroke International Workshop on Glutamic Acid Decarboxylase(GAD) Autoimmunity in Batten Disease – November 2003, Bethesda, MD
• Homogeneous PCR Nucleobase Quenching Assay to detect the 1-kbp deletion in CLN3 that causes Batten Disease
• Investigating Glutamate Exitotoxicity in Batten Disease to establish and characterize exitotoxic events that may contribute to the pathogenesis of Batten disease.
• Defective lysosomal arginine transport in juvenile Batten disease
• Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease
• “Identifying Biomarkers of JNCL”
• Attenuation of AMPA receptor activity in Batten disease
• Funding to support the continuation of the promising research of Marco Sardiello, Ph.D., at the Jan and Dan Neurological Research Institute at Texas Children’s Hospital.